Notorious as The Devil's Highway, US Route 491 in New Mexico runs from Shiprock at the North end to Gallup at the South end, about 93 miles.
Part of the Historic Route 66, this stretch was legitimately designated Route 666 until 2003 when it was changed, in part because of signage theft.
It's haunted and the name change didn't help. Ghostly visitations have been reported numerous times including motorists being charged at by a perfectly preserved 1930s-era black Packard Sedan.
Locals know not to drive The Devil's Highway at night and certainly not on the night of the full moon.